Raman Flow Cell

Brand: Endress+Hauser

Raman Flow Cell

Brand: Endress+Hauser
Extended Extended

The Raman flow cell meets the speed demands of downstream by optimizing Raman collection for low-turbidity, low volume samples. Ideally suited for development-scale flow rates, the Raman flow cell allows real-time monitoring, rapid process optimization, and process control for chromatography and other downstream unit operations.

  • Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Features
  • TheRaman flow benchhouses a Raman flow cell and easily connects to anRxn-10 probepaired with a Raman Rxn embedded analyzer, and ensures transferability when used with theRaman flow assembly calibration and verification kit
  • Provides continuous, real-time measurements with high sensitivity for development-scale flow rates
  • Achieves lower limits of detection through enhancement of the Raman signal
  • Brings Raman-based process insights and control to downstream bioprocessing unit operations

Specifications

Measuring Principle

  • Raman Spectroscopy

Temperature

  • Operating: 0 to 40 °C (32 to 104 °F)
  • Storage: -20 to 60 °C (-4 to 140 °F)

Relative Humidity

  • Storage: < 90 % Non-Condensing

Unit Dimensions (W x H x D)

  • 46 x 25 x 11 mm
  • 1.8 x 1.0 x 0.4 inch

Sampling Probe Compatibility

  • Raman Rxn-10

Sampling Optic Compatibility

  • micro flow bench

Pressure

  • Max pressure: 4.8 barg (70 psig)

Wetted Materials

  • Body: 316L stainless steel
  • Window: Proprietary material, optimized for bioprocesses
  • Surface finish: Ra 15 with Electropolish to ASME BPE SF4 finish
  • Adhesive: USP Class VI and ISO 10993 compatible

Sterilization Method

  • CIP/SIP

Process Connection

  • 5/16-24 flat bottom ferrules
  • Up to 3/16 inch OD tubing

Fluid Path Thickness

  • 2.5 mm

Flow Conditions

  • Laminar

Flow Cell Maximum Volumetric Flowrate

  • 15 mL/min
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